منابع مشابه
Neonatal alloimmune thrombocytopenia complicated by maternal autoimmune thrombocytopenia.
Neonatal alloimmune thrombocytopenia should be suspected in any thrombocytopenic infant born to a healthy non-thrombocytopenic mother. Nevertheless, the condition occurs in only 1 or 2/10 000 births.' More often transient neonatal immune thrombocytopenia results from maternal idiopathic thrombocytopenic purpura. We report the coexistence of alloimmunisation and autoimmunisation against platelet...
متن کاملMaternal autoimmune thrombocytopenia and the newborn.
That a humoral factor was the causative agent in idiopathic thrombocytopenic purpura was suggested nearly 30 years ago after the observation that mothers with the disease often give birth to children who develop transient thrombocytopenia.1 Maternal platelet autoantibodies were presumed to pass into the fetal circulation. With present techniques2 3 platelet autoantibodies are detectable in most...
متن کاملPlatelet-bound IgM in autoimmune thrombocytopenia.
Elevated levels of platelet-bound IgG (PA-IgG) are a feature of autoimmune thrombocytopenia (ATP), but it is well documented that this does not occur in all cases. This has led us to investigate the role of platelet-bound IgM (PA-IgM) in these patients using a quantitative enzyme-linked immunosorbent assay (ELISA). Forty-five determinations of PA-IgM and PA-IgG were done on 24 patients with ATP...
متن کاملSpecificity of autoantibodies in autoimmune thrombocytopenia.
In 42 patients with autoimmune thrombocytopenia (AITP) and a positive direct platelet suspension immunofluorescence test (PSIFT), the antigenic specificity of the autoantibodies was studied. Because the autoantibodies were often not detectable in the serum and additional HLA antibodies may disturb the reaction pattern with the platelet panel, we used eluates prepared from the patients' platelet...
متن کاملCyclic thrombocytopenia of apparent autoimmune etiology.
Serial studies were performed in two patients with cyclic thrombocytopenia to investigate the pathogenesis of this disorder. Mean life span of autologous platelets when platelet levels were declining was subnormal (2.4 and 0.8 days), and megakaryocytes were abundant in the bone marrow during thrombocytopenia. Megakaryocyte colony-stimulating activity could not be detected in the serum of either...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2005
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2005.01376.x